systemic lupus erythematosus — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7527	Frentizole		Beta Amyloid
	Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction		Beta Amyloid
T77491	Prezalumab	AMG 557	Others
	Prezalumab (AMG 557) is a human IgG2 monoclonal antibody against ICOSL and BAFF. Prezalumab can be used to study sjogren's syndrome cutaneous lupus erythematosus, psoriasis, systemic lupus erythematosus arthritis and sys...		Others
T76957	Belimumab	LymphoStat B	TNF
	Belimumab(LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF).Belimumab is used in the study of fatigue and in the treatment of lupus nephritis and systemic lupus erythematosu...		TNF
T3620	Solcitinib	GLPG-0778,GSK-2586184	JAK
	Solcitinib (GLPG-0778) (GSK2586184, GLPG0778) is a JAK1 inhibitor. Solcitinib may be potentially used for the treatment of psoriasis, ulcerative colitis, and systemic lupus erythematosus.		JAK
T77727	Feeblin	IRF5-IN-1	Others
	Feeblin（IRF5-IN-1） is a protein degradation inducer that specifically blocks pro-inflammatory signaling pathways associated with autoimmune diseases and can be used to study immune system disorders in the class of system...		Others
T0860L	Mefloquine	Ro215998,WR 142490,Ro-215998,Lariam,Ro 215998	Others
	Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic l...		Others
T77432	Anifrolumab	MDX-1333,MEDI-546	IFNAR
	Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of type I interferon and is used for the prevention and treatm...		IFNAR
T33883	Paramethasone Acetate	NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP	Others
	Paramethasone Acetate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects that can be used in the treatment of systemic lupus erythematosus.		Others
T81259	Rontalizumab	RhuMab IFNalpha,Anti-Human IFN alpha Recombinant Antibody
	Rontalizumab, a humanized IgG1 monoclonal antibody, targets IFN-α and is utilized in research on systemic lupus erythematosus[1].
T63284	PAD-IN-2
	PAD-IN-2 is a potent inhibitor of pad4 with an IC50 value <1 μM and can be used to study autoimmune diseases and cancers such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, cutaneous lupus erythematos...
T76825	Ruplizumab
	Ruplizumab (BG 9588), a humanized monoclonal IgG1κ antibody targeting CD40L (TNF Receptor), holds promise for research in systemic lupus erythematosus disease [1].
T72653	(R)-Elsubrutinib	(R)-ABBV-105
	(R)-Elsubrutinib ((R)-ABBV-105), a Btk inhibitor, is employed in research related to immune disorders (including rheumatoid arthritis, psoriasis, ankylosing spondylitis, asthma, systemic lupus erythematosus) and cancer.
T83217	Abetimus	LJP 394 free base
	Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering res...
T73651	Forigerimod TFA
	Forigerimod TFA (IPP-201101 TFA), a CD4 T-cell modulator, is a phosphorylated 21-amino-acid fragment derived from U1 small nuclear ribonucleoprotein 70 kDa, specifically at Ser140. It notably inhibits autophagy and is ut...
T76762	Tabalumab
	Tabalumab (LY2127399), a humanized monoclonal antibody (IgG4 type) targeting B-cell activating factor (BAFF), exhibits neutralizing activity against both membrane-bound and soluble BAFF. This compound is relevant for res...
T72035	TLR7/8/9 antagonist 2		TLR
	TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. TLR7/8/9 antagonist 2 inhibits HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM and 0,052 μM, respectively. TLR7/...		TLR
T74907	ODN 21595
	ODN 21595, a guanine-modified inhibitor targeting TLR7 and TLR9, effectively inhibits the release of IFN-α and IL-6 without exhibiting cytotoxicity. It also reduces the expression of CD86 and HLA-DR, showcasing potential...
T73650	Forigerimod
	Forigerimod (IPP-201101), a potent CD4 T-cell modulator, is a 21-amino-acid fragment of the U1 small nuclear ribonucleoprotein 70 kDa, phosphorylated at Ser140, known for its ability to inhibit autophagy effectively. It ...
T76834	Toralizumab
	Toralizumab (IDEC-131), a humanized monoclonal antibody (mAb) directed against CD40L (CD154), consists of human gamma 1 heavy chains and human kappa light chains. Specifically targeting CD40L on T cells, it inhibits CD40...
T80880	Valziflocept	BAX1810,TAK-752
	Valziflocept (BAX1810; TAK-752) is a recombinant soluble human FcγRIIb receptor designed to act as a "decoy" or "scavenger" by targeting Fc and FcγR, binding and neutralizing pathogenic IgG. Its utility lies in mitigatin...